See this week's picks from members of our sports staff.
buffalonews.com
Tampa Bay Buccaneers wide receiver Emeka Egbuka (2) runs after a catch against New England Patriots cornerback Marcus Jones,
right, during the first half of an NFL football game Sunday, Nov. 9, 2025, in Tampa, Fla. Chris O'Meara - AP
Jay Skurski
Ready for some brutal honesty? I’ve got absolutely no idea which Bills team will show up this week – or any week, for this matter. They lack any sort of consistency from week to week. They’ve got a passing game that’s broken and a defense that struggles to stop the run. So, I don’t feel great about picking them at this point of the season … but I’m still going to. The Bills have been a good home team, and the Buccaneers aren’t the picture of good health, either.
Bills, 27-20.
Katherine Fitzgerald
The Bills are able to rebound from a grotesque loss in Miami, and they take their anger out on the Tampa Bay Buccaneers. It'll be a fun matchup between quarterback Josh Allen and friend Baker Mayfield, but both teams will need to get their respective run games going at a windy Highmark Stadium. The Bills are looking slightly healthier, though the loss of tight end Dalton Kincaid looms large. Still, offensive coordinator Joe Brady finds a way to get it done, and the Bills win a close one.
Bills, 27-24.
Lance Lysowski
This could be a shootout. For the Bills to win this game, they can't allow the Buccaneers middling backup running backs, Rachaad White and Sean Tucker, to run all over them. Stopping the run would make Tampa Bay's offense one-dimensional and limit the plays it can call for quarterback Baker Mayfield, who's going to challenge the Bills' secondary with throws downfield. Can anyone cover Buccaneers rookie receiver Emeka Egbuka? Buffalo's offense will get back on track and the defense will do just enough to win.
Bills 31-24.
Steve Trosky
I'm going to go out on a limb and say that the team that runs the ball best on Sunday will win. With winds expected to be 21 mph with gusts to 34 mph and a chance of snow, throwing the ball could be an issue. When you consider the running prowess of quarterbacks Josh Allen and Baker Mayfield, expect their legs, not their arms, to determine the outcome. I suspect both teams will use spies on the opposing quarterback. The defense that does the best job wins.
Bills, 28-24.